Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 19-11-21 19:30 | 19-11-21 19:30 | FC Augsburg | FC Bayern Munique | 2:1 | 8 - 8 - 2 |
| 20-11-21 14:30 | 20-11-21 14:30 | Bor. Mönchengladbach | SpVgg Greuther Fürth | 4:0 | 2 - 8 - 8 |
| 20-11-21 14:30 | 20-11-21 14:30 | Bayer 04 Leverkusen | VfL Bochum | 1:0 | 2 - 8 - 8 |
| 20-11-21 14:30 | 20-11-21 14:30 | Borussia Dortmund | VfB Estugarda | 2:1 | 2 - 8 - 8 |
| 20-11-21 14:30 | 20-11-21 14:30 | Arminia Bielefeld | VfL Wolfsburgo | 2:2 | 8 - 6 - 2 |
| 20-11-21 14:30 | 20-11-21 14:30 | 1899 Hoffenheim | RB Leipzig | 2:0 | 7 - 4 - 3 |
| 20-11-21 17:30 | 20-11-21 17:30 | 1. FC Union Berlim | Hertha BSC Berlim | 2:0 | 3 - 4 - 6 |
| 21-11-21 14:30 | 21-11-21 14:30 | SC Friburgo | Eintracht Frankfurt | 0:2 | 3 - 5 - 5 |
| 21-11-21 16:30 | 21-11-21 16:30 | FSV Mainz 05 | 1. FC Colónia | 1:1 | 3 - 3 - 6 |