Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 16-10-21 12:30 | 16-10-21 12:29 | FC Watford | FC Liverpool | 0:5 | 2 - 4 pontos |
| 16-10-21 15:00 | 16-10-21 14:59 | Aston Villa | Wolverhampton Wanderers | 2:3 | 2 - 4 pontos |
| 16-10-21 15:00 | 16-10-21 14:59 | Leicester City | Manchester United | 4:2 | 2 - 4 pontos |
| 16-10-21 15:00 | 16-10-21 14:59 | Manchester City | FC Burnley | 2:0 | 2 - 4 pontos |
| 16-10-21 15:00 | 16-10-21 14:59 | Norwich City | Brighton and Hove Albion | 0:0 | 2 - 4 pontos |
| 16-10-21 15:00 | 16-10-21 14:59 | FC Southampton | Leeds United | 1:0 | 2 - 4 pontos |
| 16-10-21 17:30 | 16-10-21 17:29 | Brentford FC | FC Chelsea | 0:1 | 2 - 4 pontos |
| 17-10-21 14:00 | 17-10-21 13:59 | FC Everton | West Ham United | 0:1 | 2 - 4 pontos |
| 17-10-21 16:30 | 17-10-21 16:29 | Newcastle United | Tottenham Hotspurs | 2:3 | 2 - 4 pontos |
| 18-10-21 20:00 | 18-10-21 19:59 | FC Arsenal | Crystal Palace | 2:2 | 2 - 4 pontos |