Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 25-09-21 12:30 | 25-09-21 12:29 | Manchester United | Aston Villa | 0:1 | 2 - 4 pontos |
| 25-09-21 12:30 | 25-09-21 12:29 | FC Chelsea | Manchester City | 0:1 | 2 - 4 pontos |
| 25-09-21 15:00 | 25-09-21 14:59 | Leeds United | West Ham United | 1:2 | 2 - 4 pontos |
| 25-09-21 15:00 | 25-09-21 14:59 | Leicester City | FC Burnley | 2:2 | 2 - 4 pontos |
| 25-09-21 15:00 | 25-09-21 14:59 | FC Watford | Newcastle United | 1:1 | 2 - 4 pontos |
| 25-09-21 15:00 | 25-09-21 14:59 | FC Everton | Norwich City | 2:0 | 2 - 4 pontos |
| 25-09-21 17:30 | 25-09-21 17:29 | Brentford FC | FC Liverpool | 3:3 | 2 - 4 pontos |
| 26-09-21 14:00 | 26-09-21 13:59 | FC Southampton | Wolverhampton Wanderers | 0:1 | 2 - 4 pontos |
| 26-09-21 16:30 | 26-09-21 16:29 | FC Arsenal | Tottenham Hotspurs | 3:1 | 2 - 4 pontos |
| 27-09-21 20:00 | 27-09-21 19:59 | Crystal Palace | Brighton and Hove Albion | 1:1 | 2 - 4 pontos |