Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 17-09-21 20:00 | 17-09-21 19:59 | Newcastle United | Leeds United | 1:1 | 2 - 4 pontos |
| 18-09-21 12:30 | 18-09-21 12:29 | Wolverhampton Wanderers | Brentford FC | 0:2 | 2 - 4 pontos |
| 18-09-21 15:00 | 18-09-21 14:59 | FC Burnley | FC Arsenal | 0:1 | 2 - 4 pontos |
| 18-09-21 15:00 | 18-09-21 14:59 | FC Liverpool | Crystal Palace | 3:0 | 2 - 4 pontos |
| 18-09-21 15:00 | 18-09-21 14:59 | Manchester City | FC Southampton | 0:0 | 2 - 4 pontos |
| 18-09-21 15:00 | 18-09-21 14:59 | Norwich City | FC Watford | 1:3 | 2 - 4 pontos |
| 18-09-21 17:30 | 18-09-21 17:29 | Aston Villa | FC Everton | 3:0 | 2 - 4 pontos |
| 19-09-21 14:00 | 19-09-21 13:59 | West Ham United | Manchester United | 1:2 | 2 - 4 pontos |
| 19-09-21 14:00 | 19-09-21 13:59 | Brighton and Hove Albion | Leicester City | 2:1 | 2 - 4 pontos |
| 19-09-21 16:30 | 19-09-21 16:29 | Tottenham Hotspurs | FC Chelsea | 0:3 | 2 - 4 pontos |