Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 05-11-21 20:00 | 05-11-21 19:59 | FC Southampton | Aston Villa | 1:0 | 2 - 4 pontos |
| 06-11-21 12:30 | 06-11-21 12:29 | Manchester United | Manchester City | 0:2 | 2 - 4 pontos |
| 06-11-21 15:00 | 06-11-21 14:59 | Brentford FC | Norwich City | 1:2 | 2 - 4 pontos |
| 06-11-21 15:00 | 06-11-21 14:59 | FC Chelsea | FC Burnley | 1:1 | 2 - 4 pontos |
| 06-11-21 15:00 | 06-11-21 14:59 | Crystal Palace | Wolverhampton Wanderers | 2:0 | 2 - 4 pontos |
| 06-11-21 17:30 | 06-11-21 17:29 | Brighton and Hove Albion | Newcastle United | 1:1 | 2 - 4 pontos |
| 07-11-21 14:00 | 07-11-21 13:59 | FC Arsenal | FC Watford | 1:0 | 2 - 4 pontos |
| 07-11-21 14:00 | 07-11-21 13:59 | FC Everton | Tottenham Hotspurs | 0:0 | 2 - 4 pontos |
| 07-11-21 14:00 | 07-11-21 13:59 | Leeds United | Leicester City | 1:1 | 2 - 4 pontos |
| 07-11-21 16:30 | 07-11-21 16:29 | West Ham United | FC Liverpool | 3:2 | 2 - 4 pontos |