Calendário
| Competição | Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|---|
| DFB | 26-10-21 17:30 | 26-10-21 17:30 | Preußen Münster | Hertha BSC Berlim | 1:3 | 2 - 5 pontos |
| DFB | 26-10-21 17:30 | 26-10-21 17:30 | SV Babelsberg 03 | RB Leipzig | 0:1 | 2 - 5 pontos |
| DFB | 26-10-21 17:30 | 26-10-21 17:30 | TSV 1860 Munique | FC Schalke 04 | 1:0 | 2 - 5 pontos |
| DFB | 26-10-21 17:30 | 26-10-21 17:30 | 1899 Hoffenheim | Holstein Kiel | 5:1 | 2 - 5 pontos |
| DFB | 26-10-21 19:00 | 26-10-21 19:00 | Borussia Dortmund | FC Ingolstadt | 2:0 | 2 - 5 pontos |
| DFB | 26-10-21 19:45 | 26-10-21 19:45 | 1. FC Nuremberga | Hamburgo SV | 3:5a.pen. | 2 - 5 pontos |
| DFB | 26-10-21 19:45 | 26-10-21 19:45 | FSV Mainz 05 | Arminia Bielefeld | 3:2a.p. | 2 - 5 pontos |
| DFB | 26-10-21 19:45 | 26-10-21 19:45 | VfL Osnabrück | SC Friburgo | 4:5a.pen. | 2 - 5 pontos |
| DFB | 27-10-21 17:30 | 27-10-21 17:30 | Dynamo Dresden | FC St. Pauli | 2:3a.p. | 2 - 5 pontos |
| DFB | 27-10-21 17:30 | 27-10-21 17:30 | SV Waldhof Mannheim | 1. FC Union Berlim | 1:3a.p. | 2 - 5 pontos |
| DFB | 27-10-21 17:30 | 27-10-21 17:30 | Bayer 04 Leverkusen | Karlsruher SC | 1:2 | 2 - 5 pontos |
| DFB | 27-10-21 17:30 | 27-10-21 17:30 | VfL Bochum | FC Augsburg | 7:6a.pen. | 2 - 5 pontos |
| DFB | 27-10-21 19:45 | 27-10-21 19:45 | Bor. Mönchengladbach | FC Bayern Munique | 5:0 | 2 - 5 pontos |
| DFB | 27-10-21 19:45 | 27-10-21 19:45 | Hannover 96 | Fortuna Düsseldorf | 3:0 | 2 - 5 pontos |
| DFB | 27-10-21 19:45 | 27-10-21 19:45 | Jahn Regensburg | FC Hansa Rostock | 5:7a.pen. | 2 - 5 pontos |
| DFB | 27-10-21 19:45 | 27-10-21 19:45 | VfB Estugarda | 1. FC Colónia | 0:2 | 2 - 5 pontos |