Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 06-05-22 20:00 | 06-05-22 20:00 | UD Levante | Real Sociedad | 2:1 | 2 - 5 pontos |
| 07-05-22 13:00 | 07-05-22 13:00 | RCD Mallorca | FC Granada | 2:6 | 2 - 5 pontos |
| 07-05-22 15:15 | 07-05-22 15:15 | Athletic Bilbao | FC Valencia | 0:0 | 2 - 5 pontos |
| 07-05-22 17:30 | 07-05-22 17:30 | FC Cádiz | FC Elche | 3:0 | 2 - 5 pontos |
| 07-05-22 17:30 | 07-05-22 17:30 | Celta Vigo | Deportivo Alavés | 4:0 | 2 - 5 pontos |
| 07-05-22 20:00 | 07-05-22 20:00 | Real Betis Sevilla | FC Barcelona | 1:2 | 2 - 5 pontos |
| 08-05-22 13:00 | 08-05-22 13:00 | FC Getafe | Rayo Vallecano | 0:0 | 2 - 5 pontos |
| 08-05-22 15:15 | 08-05-22 15:15 | FC Villarreal | FC Sevilla | 1:1 | 2 - 5 pontos |
| 08-05-22 17:30 | 08-05-22 17:30 | Espanyol Barcelona | CA Osasuna | 1:1 | 2 - 5 pontos |
| 08-05-22 20:00 | 08-05-22 20:00 | Atlético Madrid | Real Madrid | 1:0 | 2 - 5 pontos |