Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 15-04-22 20:00 | 15-04-22 20:00 | Real Sociedad | Real Betis Sevilla | 0:0 | 2 - 5 pontos |
| 16-04-22 13:00 | 16-04-22 13:00 | FC Elche | RCD Mallorca | 3:0 | 2 - 5 pontos |
| 16-04-22 15:15 | 16-04-22 15:15 | Deportivo Alavés | Rayo Vallecano | 1:0 | 2 - 5 pontos |
| 16-04-22 17:30 | 16-04-22 17:30 | FC Valencia | CA Osasuna | 1:2 | 2 - 5 pontos |
| 16-04-22 20:00 | 16-04-22 20:00 | FC Getafe | FC Villarreal | 1:2 | 2 - 5 pontos |
| 17-04-22 13:00 | 17-04-22 13:00 | FC Granada | UD Levante | 1:4 | 2 - 5 pontos |
| 17-04-22 15:15 | 17-04-22 15:15 | Atlético Madrid | Espanyol Barcelona | 2:1 | 2 - 5 pontos |
| 17-04-22 17:30 | 17-04-22 17:30 | Athletic Bilbao | Celta Vigo | 0:2 | 2 - 5 pontos |
| 17-04-22 20:00 | 17-04-22 20:00 | FC Sevilla | Real Madrid | 2:3 | 2 - 5 pontos |
| 18-04-22 20:00 | 18-04-22 20:00 | FC Barcelona | FC Cádiz | 0:1 | 2 - 5 pontos |