Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 02-04-22 13:00 | 02-04-22 13:00 | FC Getafe | RCD Mallorca | 1:0 | 2 - 5 pontos |
| 02-04-22 15:15 | 02-04-22 15:15 | UD Levante | FC Villarreal | 2:0 | 2 - 5 pontos |
| 02-04-22 17:30 | 02-04-22 17:30 | Celta Vigo | Real Madrid | 1:2 | 2 - 5 pontos |
| 02-04-22 20:00 | 02-04-22 20:00 | Atlético Madrid | Deportivo Alavés | 4:1 | 2 - 5 pontos |
| 03-04-22 13:00 | 03-04-22 13:00 | Athletic Bilbao | FC Elche | 2:1 | 2 - 5 pontos |
| 03-04-22 15:15 | 03-04-22 15:15 | Real Betis Sevilla | CA Osasuna | 4:1 | 2 - 5 pontos |
| 03-04-22 17:30 | 03-04-22 17:30 | FC Granada | Rayo Vallecano | 2:2 | 2 - 5 pontos |
| 03-04-22 17:30 | 03-04-22 17:30 | FC Valencia | FC Cádiz | 0:0 | 2 - 5 pontos |
| 03-04-22 20:00 | 03-04-22 20:00 | FC Barcelona | FC Sevilla | 1:0 | 2 - 5 pontos |
| 04-04-22 20:00 | 04-04-22 20:00 | Real Sociedad | Espanyol Barcelona | 1:0 | 2 - 5 pontos |