Calendário
| Data | Prazo para submeter os prognósticos | Casa | Visitante | Resultado | Regra de pontuação |
|---|---|---|---|---|---|
| 05-11-21 20:00 | 05-11-21 20:00 | Athletic Bilbao | FC Cádiz | 0:1 | 2 - 5 pontos |
| 06-11-21 13:00 | 06-11-21 13:00 | Espanyol Barcelona | FC Granada | 2:0 | 2 - 5 pontos |
| 06-11-21 15:15 | 06-11-21 15:15 | Celta Vigo | FC Barcelona | 3:3 | 2 - 5 pontos |
| 06-11-21 17:30 | 06-11-21 17:30 | Deportivo Alavés | UD Levante | 2:1 | 2 - 5 pontos |
| 06-11-21 20:00 | 06-11-21 20:00 | Real Madrid | Rayo Vallecano | 2:1 | 2 - 5 pontos |
| 07-11-21 13:00 | 07-11-21 13:00 | FC Villarreal | FC Getafe | 1:0 | 2 - 5 pontos |
| 07-11-21 15:15 | 07-11-21 15:15 | FC Valencia | Atlético Madrid | 3:3 | 2 - 5 pontos |
| 07-11-21 17:30 | 07-11-21 17:30 | CA Osasuna | Real Sociedad | 0:2 | 2 - 5 pontos |
| 07-11-21 17:30 | 07-11-21 17:30 | RCD Mallorca | FC Elche | 2:2 | 2 - 5 pontos |
| 07-11-21 20:00 | 07-11-21 20:00 | Real Betis Sevilla | FC Sevilla | 0:2 | 2 - 5 pontos |